中文名:鸟苷-5’-二磷酸二钠盐
CAS:7415-69-2
品牌:MedChemExpress (MCE)
存储条件:-20°C, sealed storage, away from moisture
生物活性:Guanosine 5'-diphosphate (GDP) disodium salt 是一种核苷二磷酸盐,可激活腺苷 5'-三磷酸敏感的 K+ 通道。 Guanosine 5'-diphosphate disodium salt 是一种潜在的铁动员剂,可阻止hepcidin-ferroportin 相互作用并调节interleukin-6 (IL-6)/stat-3 通路.鸟苷5'-二磷酸二钠盐可用于炎症研究,如炎症性贫血(AI)[1][2]。 IC50 和目标:K+ 通道[1],内源性代谢物[2]。
参考文献:
[1]. Angmo S, et al. Identification of Guanosine 5'-diphosphate as Potential Iron Mobilizer: Preventing the Hepcidin-Ferroportin Interaction and Modulating the Interleukin-6/Stat-3 Pathway. Sci Rep. 2017 Jan 5;7:40097.[2]. S Kajioka, et al. Guanosine diphosphate activates an adenosine 5'-triphosphate-sensitive K+ channel in the rabbit portal vein. J Physiol. 1991 Dec;444:397-418.
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