Deciphering Natural Code: The Ruan YuHua Syndrome Is a Crucial Key Bases the Study Not Only on Upper Respiratory Infection, But on Involved or Predisposed Chronic Systemic Diseases
解码自然：阮玉华综合征不仅是研究上呼吸道感染的关键，也是很多常见的慢性疾病病因探索和治疗
Yong Tan
20 October, 2024
Preface: Ruan YuHua syndrome (RS) superficially is a set of clinical manifestations presenting on subject which is the ethanol can be taken in by nasal mucosa on which, different gradient of osmolality can induce respectively phenotype of ethanol affecting Central Nervous System (CNS). From this pathogenesis, an novel transportation spanning between nose and cranial bottom thus we inferred in treating Long COVID is interest which transpires a process that the Upper Respiratory Infection (UPI) with which the nasal virus brings you, to which, how does it affect the Automatic Nervous System (ANS) of yours and its physiological functions involves automatically maintaining you in surviving and for which; in this prose, we will anatomize a stunning extra-transportation system (ETS) responsible to secure the energy of supplying ANS. And, by the way, how the URI develops conditions; on the perspective of realism, this revealed pathogenesis may render the chronic diseases occurring and development.
前言：阮玉华综合征表面是一组临床表现指向病人的鼻黏膜吸收酒精后，不同的溶液渗透压可诱导出不同的中枢神经的影响。这是一个新发现跨鼻腔与颅内的传输系统揭示了上呼吸道感染病毒如何影响你的自主神经系统，平时这些系统用来维持你的生命。本文中，我们将讲解一个让你震撼的附加传输系统来保证能量供应。对于自主神经系统来说，上呼吸道感染是如何利用这个系统来致病的。站在一个现实的角度，阮玉华综合征揭示了相关慢性病的演绎。
Keywords: Ruan YuHua Syndrome, Upper Respiratory Infection, Glucose, Glycolysis Metabolism, Cerebrospinal Fluid, Frozen Shoulder.
关键词：阮玉华综合征，上呼吸道感染，葡萄糖，葡萄糖酵解，脑脊液，肩周炎。
To elaborate this subject, we have briefly to have an anatomy on CNS nutrition circulation. According to our cramming [1]. The blood, heart pumps through arteries into cranium when till flowing in cranial capillary, which serum encounters with a biological barrier we call Blood-Brain-Barrier (BBB) it functions amounting to a sieve which pores only just permit nutriments entry into a pool filled with Cerebrospinal Fluid (CF); the other matters serum conveys, such as blood cells, platelet, neurotoxic agents, and pathogens all be forbidden.
想说清楚问题，首先我们短暂介绍中枢神经的滋养循环。 按照一贯的认知 【1】，血液由心脏经动脉灌入颅腔内，到了毛细血管阶段，经由生物筛子—血脑屏障过滤，营养物质进入一个大容器内，血浆其它成分，如血细胞、血小板、有毒物质或病原体被挡在门外。
It can be seen that the absolutely soft and vulnerable CNS is actually immersing in a nutrient fluid to exert their physiological function thorough body. The CF which dynamic is flowing from the surface of cerebrum down to lumbar where, BBB besides offering nutrition, also fulfills the final absorption to let metabolites yielded by CNS acquired back into circulatory system; the CNS alimentation circulation accomplishes. What is more, in order to take sample of CF for laboratory testing, lumbar is the relatively safe site for puncture with less adverse affection on body. The other sites are absolutely forbidden for probably severely hurt taking place on the nerves. For example, the cervical vertebra trauma can lead to patient to die in the case of hurt on medullas oblongata to cause the nuclei of cranial nerve X dysfunctions, or with loss the voluntary motion below neck.
由此可见，脆弱又柔软的脑组织其实是泡在一个容器里，里边充满含营养物质的脑脊液，从此脑组织操控全省。脑脊液的流动也由脑顶部到腰椎，再由那里的血脑屏障做最后的回收入循环系统，完成中枢神经的滋养循环过程。还有，腰椎作为临床医学提取脑脊液样本的理想穿刺位置，其他部位是一律禁止，因为危险。比如颈椎，可以造成病人因延髓损伤到第Ⅹ颅神经功能衰竭而死亡或高位截瘫。
Meanwhile, to human, another external danger imposed on whom from milieu how to evade is a vital option to survive. Take a man to hunter as being instance, as well as other species human have themselves a position in the food chain as either a predator or a prey. When in their hunting besides dedicatedly follows the trace prey left; however, concurrently, they must keep their vigilance on everything surrounding themselves on whom the supposed big cat, by bush, would pounce. Just as this reason, as long as smell a truce of danger, as alarm, it would scare human to escape from that site.
同时，对于人类避免周围环境强加的危险也是一个至关重要的生存功课。拿他们狩猎做例子，人与其它动物一样，在食物链上占有一席之地，既是捕食者也是他人的猎物。这决定了人除了细心追踪猎物外，还得注意自己周边的动静，以防突然窜出灌木丛扑向自己的大猫。基于这个生存理由，只要嗅到一丝危险，人会立马逃窜。
Inside the cranium of creatures, these basal ganglia, which compose the nucleus of ANS lying on the bottom of cranium responsible to an involuntary maintaining on metabolism all over the body other than skeletal muscles do with the voluntary motion; are required to engage in coordination. These neurons in ganglia thus are activated in excitement to demand their ganglions outside cranium further to up/downregulate the metabolism of involved organs aiming to reach body out in urgent response, fight or flight, is nothing to these nuclei but for employ them, body must be responsible for their instantly burden to whom their consuming energy giving rise, sharply increasing glucose embodies.
在这只动物的脑中，有一串神经核位于脑底部（基底节），平素负责管理生物的基本代谢，与身体肌肉的活动是由生物主动发出指令控制不同，这种核被称为“自主神经核”，其活动是不知不觉中进行。现在被要求参与到紧急应对的活动中，核心因此被激活，向颅脑外神经节发出各种指令以或高或低地调节相关脏器的代谢以做配合。那么生物是战斗还是逃跑其实部重要，对于这些自主神经核来说，解决为应急刺激而产生的临时能量消耗陡然上升的问题才是关键，具体是葡萄糖的供应。
While drawing on BBB mechanism above-mentioned to supply glucose for the ANS, though there is less of literatures over estimating this subject, down the flowing router we can still deduce the job is not bad but apparently less of efficient to accommodate that urgent demand from ANS since we know glucose in CF which peak of concentration is always lagged to in serum [2]; second, in order to accelerate the CF flowing to raise intracranial stress also seems impractical for a threshold is over there, or cranial capillary would burst for over high blood pressure. The alternative addressing to collect an extra share of glucose becomes crucial key to survive creatures.
回头看血液到血脑屏障的供应模式，虽然不错，显然可见缺乏效率应对危机处理，而且脑脊液的葡萄糖浓度的提升是滞后血浆的【2】；另一方面，加快脑脊液的流动是要升高脑压，这也是有一个极限值，超过可能会导致颅内毛细血管破裂。另一个办法是设法找到一个额外的供应。
Talk in RS, as a pathogenesis, it shows ethanol mediated to irritate medulla oblongata with pain or cerebellum thus body loses more or less coordination in motion. Alternatively, in the case of considered as a physiological function, what does it transport? The answer may it be used to transfer glucose in tissue that near to cranial bottom to meet with the urgent demand from nucleus of ANS; i.e., RS is actually that ETS.
说起阮玉华综合征（RS）显示的是酒精被调剂入颅底去刺激延髓或小脑导致疼痛和身体活动失去协调。那么，如果RS是一个正常的生理功能又会是调剂什么物质入颅腔？答案是葡萄糖，从颅底组织榨取的，用来满足自主神经系统的应急使用。就是说RS就是前面说的附加的运输系统。
This novel physiological mechanism is readily to answer why the ANS would be damaged for patients with URI. These colonies of nasal virus likewise are capable of mediating glucose into cranium from nasal membrane for their causing inflammation as similar case in RS. Although glucose is a matter human uptake as the sort of energic material, yet the hyperglycemia can damage tissues, and the same does hyperglycorrhachia to CNS with neurotoxicity for which, there happens to two aspects: CF in hyperosmolality leads to either myelin sheath or neuron in atrophy; second, the lactate the metabolite of anaerobic glycolysis can precipitate.
这套生理功能也很容易用来解释上呼吸道感染是如何损伤自主神经系统的。鼻病毒通过对鼻黏膜的感染调剂葡萄糖入颅内。尽管葡萄糖是维持我们生存的能量物质，但高糖如同糖尿病一样会损伤组织，脑脊液高糖会表现出神经损伤，因为高糖能提高脑脊液的渗透压造成细胞功能性萎缩；同时，葡萄糖无氧酵解的乳酸产物也是加重损伤的因素。
Well, our hypothesis holding seems of less evidence. The first cause may be our bio-mark in CF with being upregulated; such tone likes sophism, at all events, it seems plausible for calling interrogation.
那么，我们的假设似乎缺乏证据支持。第一个理由可以是一个逻辑问题：现行的脑脊液测定值被调高了。这个调调看似有点狡辩的味道。
When we identify a cohort of subjects health for taking their sample of CF from lumbar, maybe we departed from a wrong premise--the definition on health the people are not more than one without symptoms of URI; whereas, it does not amount to no affection virus inhabiting in nasal membrane to impact CF. Whereas the case of subjects with URI, however, why the CF glucose presents nothing its concentration in fluctuating in testing even if there is obvious evidence to show viral invasion in CF [2]?
当我们认定一组对象是健康的并提取他们的脑积液，可能会忽略一个事实：经管对这组健康的定义是没有上呼吸道症状，但无法确定是否存在病毒对脑脊液施加影响而影响到测定值。但无论如何也解释不了葡萄糖的值是相当稳定的，即使是有证据现实病毒直接入侵脑脊液，葡萄糖浓度也不会降低。
Therefore, we have to concern the challenge that lumbar may not be the unique site for final absorbing CF; maybe exists another one exclusively serves ETS.
因此，我们不得不面对一个难题：腰椎是否是唯一吸收脑脊液的部位。也许有其它。
An interesting disease which may decipher the code of that is the Frozen Shoulder (FS) be described scapulohumeral stiffness or pain inhibit arms motion [3]; even more patients initially merely complain on their neck posterior muscles in insistence accompanying with soreness both to stop their neck rotation upon either transverse plan, sagittal plan, or mixed. And, their conditional alleviation can be acquired with an extent in a short-term by massage or heating on neck lesion they suppose.
一个有趣的疾病可能可以解释这个现象，那就是“肩周炎”。它被描述为肩部肌肉僵硬或疼痛导致手臂活动受限或停止 【3】；更多的是病人感觉颈后肌肉有阻力并酸痛使得颈部转动受限。这个病可以短期通过按摩和热敷改善。
This condition can be cited that Despite over a hundred years of treating this condition the definition, diagnosis, pathology and most efficacious treatments are still largely unclear [4]. In [3] it counsels there is inflammation on joints nor does clarify what is matter to lead.
这个病被评为尽管一百年来的治疗和确诊，但依然搞不清病因 【4】。一般建议是关节 【3】周边发炎但引起发炎的物质不明。
Of cause, the condition presents with involved to skeletomuscular system, maybe on this ground, people for granted put their focus on patients’ history if they did over exercising, long-term wrong posture ever had kept; the existence of trauma or irritation. An inexplicable correlation is relevant to Diabetes Mellitus in 20% patients; moreover, while you find your shoulders frozen and in between the ages of 40 and 60, the peak incidence of age range; may be predisposed to prediabetic condition [4,5].
当然，疾病部位在骨骼肌很容易大家的视线会落在病人有过度活动或长时间保持错误姿势，创伤或被刺激到，等等。另一个无法解释的是该病与糖尿病关系密切，20%的病人同时患糖尿病；而且发病高峰年龄段在40~60岁。反过来，如果你患有，那么意味着你患糖尿病的可能性剧增 【4，5】。
Consider a case: shoulder muscles with higher lactate since an amount of acid compound being absorbed by BBB in cervical vertebra for access to circulatory system; to fulfill this process, maybe the higher concentration CO2 deposited in many of nasal sinus assists but so far it is sadness that the correlative pathogenesis has been unknown.
想想：肩和颈肌肉会堆积乳酸因为有相当数量的乳酸经由颈椎的血脑屏障吸收，完成附加的传输循环。期间，鼻窦的高二氧化碳浓度可能协助这个过程，目前，很遗憾还是未得到证实。
The FS has been actually a specific signal to alert the URI begin a progress of chronic impairment on these ganglia whereas, we have long to choose to rule out this message. On the other hand, to this case, the nasal viral disinfection is observed to always efficacious in dissipating the pain or stiffness at neck posterior, even to arm numb and results in a nice prognosis; concurrently, makes a corrective diagnosis about cause.
肩周炎实际上向我们发出上呼吸道感染开启慢性损伤基底节的过程，我们却一直忽略。另一方面，在这个病例中，我们发现鼻腔病毒有效消杀通常能够驱散肩部和颈部的肌肉僵硬和酸痛，甚至手臂麻木的症状也消失了。同时，治疗效果也支持了上呼吸道感染的诊断。
Consequently, underlaid by a novel neuropathological mechanism derived from RS that sounds a topic lesion on cranial bottom involved to disturb our metabolism. From now, we can have a clear cognization on some chronic diseases, such as hypertension, myalgia, malaise, fatigue, diabetes mellitus type II, sudden cardia death, …, involved to kidney, liver, or multi sclerosis, … all are likely concerned by involved to URI or other factors impairment on the cranial nerve X.
因此，基于这样的，衍生自RS的神经病理机制说明了颅脑底部的局部病变能扰乱身体的代谢。从现在开始，我们有了一个清晰的认知对于常见的慢性病，譬如高血压，莫名的肌肉疼痛，全身不适，疲劳，2型糖尿病，心源性猝死，等等，相关到肾脏，肝脏或多发性硬化症，等等，所有的病例都能与上呼吸道感染损伤第X对颅神经相关。
Reference
[1] Sweeney MD, Zhao Z, Montagne A, Nelson AR, Zlokovic BV. Blood-Brain Barrier: From Physiology to Disease and Back. Physiol Rev. 2019 Jan 1;99(1):21-78.
[2] BRIAN SHAHAN, et.al. Cerebrospinal Fluid Analysis. Available till 16 Oct, 2024; https://www.aafp.org/pubs/afp/issues/2021/0401/p422.html
[3] Frozen Shoulder. Available till 16 Otc, 2024; https://www.hopkinsmedicine.org/health/conditions-and-diseases/frozen-shoulder
[4] Le HV, Lee SJ, Nazarian A, Rodriguez EK. Adhesive capsulitis of the shoulder: review of pathophysiology and current clinical treatments. Shoulder Elbow. 2017 Apr;9(2):75-84.
[5] Uppal HS, Evans JP, Smith C. Frozen shoulder: A systematic review of therapeutic options. World J Orthop. 2015 Mar 18;6(2):263-8.返回搜狐，查看更多
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